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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cholestyramine Resin
supplement:
Psyllium
Research Papers that Mention the Interaction
“ Psyllium and cholestyramine both had significant hypocholesterolemic effects, but in combination produced additive reductions in lipoprotein and hepatic cholesterol.”
“Recent findings suggest that the effects of cholestyramine and psyllium in combination could be additive for cholesterol-lowering.”
Additive hypocholesterolemic effect of psyllium and cholestyramine in the hamster: influence on fecal sterol and bile acid profiles.“Although the … as much cholestyramine … psyllium (4%) LDL-C production decreased from 288 +/- 15 to 187 +/- 17 micrograms/h per 100 g body weight, the suppression of LDL-… 41 +/- 5 mg/dl, and hepatic cholesterol content decreased from 17.1 +/- 1.9 to 2.4 +/- 0.1 mg/g.”
“We wished to determine the … of submaximal doses of cholestyramine … psyllium given in combination in reversing dietary-induced hypercholesterolemia in Golden Syrian hamsters, and to investigate the mechanism or mechanisms of action through which these agents together decrease plasma low density lipoprotein cholesterol (LDL-C) levels in this model.”
“The pool of bile acid in the small intestine was increased from the control value (17.9 mumol/animal) by both psyllium (23.0 mumol) and cholestyramine (21.9 mumol) feeding.”
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