supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Cholestyramine Resin
supplement:
Niacin
Research Papers that Mention the Interaction
“When used as single agents, the bile-acid sequestrants, cholestyramine and colestipol, lower LDL cholesterol concentrations by 20% to 35% in compliant patients, whereas decreases of 20% to 30% can be achieved with nicotinic acid in doses of 3 to 6 g/day.”
Treatment of heterozygous familial hypercholesterolemia with lipid-lowering drugs.“The addition of niacin and mevinolin to the cholestyramine regimen had incremental effects and the 3-drug regimen reduced the total cholesterol level.”
“In one of these patients a combination of nicotinic acid plus cholestyramine lowered the plasma cholesterol level and abolished the skin lesions; in the other, this combination improved the skin lesions but did not cause a sustained fall in plasma cholesterol level.”
“It is suggested that a combination of cholestyramine and nicotinic acid decreases the mass of exchangeable cholesterol in the body by increasing cholesterol removal and inhibiting the compensatory increase in hepatic cholesterol synthesis that would otherwise occur in response to increased removal.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback