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“Cholestyramine therapy has been associated with malabsorption of vitamins; several reports suggest that cholestyramine affects absorption of the fat-soluble vitamins K and D and, in addition, may alter water-soluble vitamins, including folic acid.”
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition • 1991 | View Paper
“ Cholestyramine (20 mg) adsorbs 95% of pteroylglutamate or amethopterin (100 micrograms) in vitro.”