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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Cholecystokinin
supplement:
Trypsin
Research Papers that Mention the Interaction
“ CCK significantly (p<0.05) increased bilirubin, amylase and trypsin output both during normo- and hyperglycemia.”
Effect of acute hyperglycemia on basal and cholecystokinin stimulated exocrine pancreatic secretion in humans.“The results of correlation analysis showed significant correlations (p < 0.05) between plasma CCK concentration and secretion of α-amylase and trypsin.”
Regulation of pancreatic exocrine secretion in goats: differential effects of short- and long-term duodenal phenylalanine treatment.“Diversion of pancreatic juice from the duodenum stimulates cholecystokinin release and pancreatic enzyme secretion, and intraduodenal administration of trypsin or chymotrypsin inhibits cholecystokinin release and pancreatic secretion.”
“ CCK octapeptide (CCK-8) dose dependently increased trypsin and lipase output in healthy humans.”
“This inhibitory effect of trypsin on CCK release was dose dependent and specific to proteases.”
“These results indicate that both intraluminal bile and trypsin exert a negative feedback effect on the release of CCK in humans.”
“There is controversy over whether intraduodenal trypsin inhibits release of CCK in man.”
“ Cholecystokinin stimulated the pancreatic secretion of trypsin , amylase, and lipase, the emptying of bile acids, and the release of gastrin, but the patients' responses were only half that of the controls.”
“Outputs of trypsin , chymotrypsin, lipase and protein showed a bell-shaped dose response to increasing doses of cholecystokinin , with maximal outputs occurring in response to secretin plus cholecystokinin 0.5 IDU·kg−1·h−1.”
“Perfusion of the duodenum with bovine trypsin (1 g/L) reduced the plasma CCK levels to basal values and significantly attenuated the phenylalanine-stimulated enzyme secretion to 63% +/- 4% of control.”
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