[Absence of effect of secretin and cholecystokinin on plasma concentrations of vasoactive intestinal polypeptide and pancreatic glucagon].

 (CCK) on pancreatic alpha cells are contradictory.

Sensory signal transduction in the vagal primary afferent neurons.

 also occurs at the nodose ganglia; this is mediated by high affinity CCK-A receptor.

The effects of cholecystokinin-pancreozymin (CCK-PZ) on the movement of the terminal part of the bile duct in rabbits and humans

 but it was not affected by pretreatment with vagotomy.

Neuronal control of pancreatic exocrine secretion

I t has also been shown that the potentiated secretory response to infusions of

 together in physiological doses may be significantly influenced by atropine [8].

Determination of pancreatic elastase with new chromogenic substrates-p-nitroanilides of N-acyltripeptides.

 stimulation of the exocrine pancreas were significantly higher in the control subjects than in patients in whom other secretion values were altered.

Preparation and specificity of antiserum to synthetic secretin and its use in a radioimmunoassay (RIA).

 crossreacted weakly (0.03%) probably as a result of contamination with 

The hormonal regulation of pyloric sphincter function.

 was additive at submaximal concentrations but potentiation of the maximal responses was not observed.

Effects of chronic alcohol abuse on exocrine pancreatic secretion in man

Peak concentration and output of total proteins after sequential stimulation with

 was elevated significantly in chronic alcoholics when compared to nonalcoholic subjects.

Hormonal control of gastrointestinal motility

, gastrin, motilin, VIP, and glucagon stimulate contractions, while 

Modifications of pure human pancreatic juice induced by chronic alcohol consumption

Protein concentration was significantly greater in alcoholic patients than in nonalcoholic controls in the samples following both

 injections, and the highest observed protein concentration was significantly greater in alcoholic controls than in nonalcoholic controls.

Pancreatic secretion after secretin and cholecystokinin stimulation in chronic alcoholics with and without cirrhosis

 (CCK-PZ) resulted in highly significant increases in volumes during both phases of pancreatic stimulation in AC compared to NAV and CA.

Secretion of pancreatic enzymes

In two-thirds of the patients with cirrhotic livers, the volume of duodenal aspirate obtained after infusion of

 exceeded the highest volume previously recorded in a sample of normal men.

Potentiation of cholecystokinin and secretin-induced pancreatic exocrine secretion by endogenous insulin in humans.

After infusion of glucose, the plasma insulin and C-peptide levels were significantly increased and remained at high levels during 30-min experiments, intravenous administration of

 resulted in significant increases of pancreatic secretion including volume, bicarbonate, and protein output.

Effect of cholecystokinin and secretin on somatostatin release from cultured antral cells.

 resulted in a potentiation of somatostatin release, with the greatest response at 10(6) mol/L secretin, resulting in a 12-fold increase above basal.

Finally, these data indicate that the inhibitory action of

 on gastric acid secretion may result from a synergistic action on antral D cells to release somatostatin, which in turn decreases antral gastrin release.

[Diagnosis of biliary dyskinesia after cholecystectomy].

 for one hour resulted in an accelerated bile flow in the majority of these patients, which is the normal reaction of the biliary system under stimulation.

Cholecystokinetic and pancreozymic effect of O-sulfated gastrin compared with nonsulfated gastrin and cholecystokinin.

 on pancreatic secretion of juice and bicarbonate.

Decrease in plasma amino acid level after secretin and pancreozymin as an indicator of exocrine pancreatic function.

 (1 Ivy dog unit/kg X h), amino acid concentrations decreased maximally by 31% +/- 19% (mean +/- SD) in controls, … only by 6.3% +/- 4.7% in patients with exocrine pancreatic insufficiency (p less than 0.001 vs. controls).

The significance of plasma CCK and secretin in the oleate-stimulated pancreatico-biliary secretion in man

Furthermore, the bicarbonate secretion and the flow rate elicited by

, whereas no augmentation was found with regard to the CCK-stimulated enzyme and bile salts output.

Effect of low dose secretin and caerulein on pure pancreatic bicarbonate secretion and plasma secretin in man.

 may indeed play a physiological role in the regulation of duodenal pH.

Calcitonin and exocrine pancreatic secretion in man: inhibition of enzymes stimulated by CCK-pancreozymin, caerulein, or calcium—no response to vagal stimulation 12

) or secretin plus caerulein, enzyme secretion was promptly reduced by an infusion of calcitonin of more than 50%.

[Clinical significance of the tests used in the diagnosis of pancreatic diseases].

The pancreatic exocrin function can be assessed by examining the duodenal contents after intravenous administration of

Amylase activity of parotid saliva in acute and chronic pancreatitis.

 produced a significant increase in the parotid salivary amylase levels in both the patients without pancreatic disease and in those with chronic relapsing pancreatitis between acute attacks.

Response to jejunal acidification in man. I. Changes in composition of perfusate.

 increased acid disposal, particularly in patients with duodenal ulcer, and increased the associated rate of secretion of water and electrolytes or changed net absorption to net secretion.

Effects of secretin and cholecystokinin on motor activity of human jejunum. A radiotelemetering study of jejunal motility during secretin and cholecystokinin intravenous infusion.

 stimulated the spontaneous motor activity of this part of the small intestine.

Letter: Disaster wound treatment.

As shown, for example, by Barton et all and Goebell,2 elevated serum levels of pancreatic lipase and amylase may be found after the administration of

 (pancreozymin) to patients with pancreatic disease.

Letter: Plasma CEA concentrations in pancreatic disease.

Letter: Respiratory function in rheumatoid arthritis.

A comparison between secretin alone and sequential and simultaneous secretin and cholecystokinin administration in the assessment of pancreatic function 1

A comparison of secretin alone with simultaneous

 showed that the combination yielded a significantly higher trypsin concentration.

The action of secretin and pancreozymin on small-intestinal alkaline phosphatase

Following the intravenous administration of both

 there is a large rise in the output of alkaline phosphatase in human duodenal juice.

Motor responses of the sigmoid colon and rectum to exogenous cholecystokinin and secretin.

 inhibited basal motor activity of the sigmoid.

The Development of Specific Responses of the Exocrine Pancreas to Pancreozymin and Secretin Stimulation in Newborn Infants

 stimulations yield an increment of pancreatic secretion rates; differences between the responses to pancreozymin and secretin have been observed but are statistically … statistically significant differentiated response to each of the two hormones appeared only in premature newborn infants at 1 month of age.

Effect of secretin and cholecystokinin on gastric emptying and gastric secretion in man.

Inhibition of acid secretion similar in magnitude to that produced by

 was observed following the administration of 

A comparison of the response to secretin, pancreozymin and a combination of these hormones, in man.

 (16 units per kg each hour) combined with a barely suprathreshold dose of 

 (0.25 units per kg each hour) elicited a bicarbonate response as great as the response to a high dose rate (4 units per kg each hour) of secretin alone.

Effect of secretin and cholecystokinin-pancreozymin extracts on gastric motility in man.

 were also found to inhibit gastric acid secretion and to exceed 

 preparations in potency (Gillespie and Grossman, 1964; Jordan and De la Rosa, 1965).

Secretin is not necessary for exocrine pancreatic development and growth in mice.

However, camostat has also been reported to stimulate secretin release and, because

, it could participate in the growth response.

Effects of gastrointestinal hormones on vascular smooth muscle

 elicited responses when given in combination, and the effects of the hormones at all doses were potentiated by theophylline, indicating an interaction between these hormones on rat portal vein that may involve cyclic AMP.

Effect of prolonged infusion of maximal and supramaximal doses of pancreozymin on pancreatic enzyme secretion in the rat-exhaustion or inhibition?

 (2 and 4 units/100 g · 10 min) were used only in combination with 

Candidate canine enterogastrones: acid inhibition before and after vagotomy.

 are somewhat more potent and efficacious inhibitors of acid secretion than 

 but that all three peptides are far more active than GLP-1, neurotensin, and oxyntomodulin.

Secretin potentiates guinea pig pancreatic response to cholecystokinin by a cholinergic mechanism.

 resulted in a marked potentiation of the secretory responses in the exocrine guinea pig pancreas by a mechanism that involves cholinergic interactions present at the tissue level but not at the dispersed secretory cell level.

, there was a significant increase in pancreatic, compared with cholecystokinin alone.

The Role of Insulin in the Interaction of Secretin and Cholecystokinin in Exocrine Secretion of the Isolated Perfused Rat Pancreas

 is able to potentiate the pancreatic enzyme secretion stimulated by 

Secretin potentiates cholecystokinin‐stimulated amylase release by AR4‐2J cells via a stimulation of phospholipase C

 potentiated the acinar cell secretory response to 

 by cAMP‐mediated cross‐talk with the PLC signal transduction pathway.

[The Longmire gastrectomy in the animal model: postoperative changes in fat resorption and the hormones cholecystokinin and secretin].

In the gastrectomized group, higher baseline levels of both

Alterations of pancreatic amylase secretion in the reserpinized rat model of cystic fibrosis

 analog prevented recovery of the secretory responses to Cch and 

 observed in the absence of any treatment.

Intraduodenal Acid Augments Oleic Acid (C18)‐Induced Cholecystokinin Release

This potentiated response has been attributed to interactions between endogenously released

Local versus peripheral blood administration of cholecystokinin‐8 and secretin on pancreatic secretion in calves

 at 100 pmol kg‐1 were administered concomitant with reversible cold vagal blockade.

Potentiation of Acid‐Induced Pancreatic Bicarbonate Output by Amino Acid Is Mediated by Neural Elements, but Not by Circulating Cholecystokinin

[Inhibitory effect of somatostatin analogue, SMS 201-995, on secretin-stimulated exocrine secretion in isolated perfused rat pancreas].

The inhibitory effect of SMS was dose-dependent and maximal inhibition was observed …. Half-inhibitory dose of SMS for juice secretion was 140 pM. Because

 action on the ductal system, we examined the effect of SMS … response to 10 pM secretin in combination with 10 pM CCK.

Effects of cholecystokinin on cytosolic calcium in pancreatic duct segments and ductal cells.

Although the gastrointestinal peptide cholecystokinin 

) has been shown to increase bicarbonate and water secretion and potentiate the effects of 

 on pancreatic ducts, CCK receptors have not been identified on pancreatic ductal epithelium.

Role of endogenous nitric oxide in the control of canine pancreatic secretion and blood flow.

Sham-feeding, meal feeding, and infusion of

 induced pancreatic protein outputs reaching, respectively, 30%, 74%, and 50% of cerulein maximum in these dogs.

The effects of intravenous cholecystokinin, secretin and pentagastrin on electromyographic activity of the rumen in sheep

, or the single dose of pentagastrin, with the lowest dose of 

 resulted in a potentiation of their inhibitory effects.

Pancreatic, hepatic, and duodenal mucosal bicarbonate secretion during infusion of secretin and cholecystokinin. Evidence of the importance of hepatic bicarbonate in the neutralization of acid in the duodenum of anaesthetized pigs.

 on both hepatic and pancreatic bicarbonate secretion, but the hepatic production of bicarbonate was still larger than the pancreatic production.

Potentiating Effect of CCK and Secretin on Rat Exocrine Pancreas and its Cholinergic Dependence

We investigated whether physiological doses of

 (CCK) potentiate the stimulating effect of a physiological dose of 

 on exocrine pancreatic secretion, and the effect of atropine on this potentiating action in rats.

Role of Cholecystokinin in Pancreatic Bicarbonate Secretion in Dogs

In a group of four dogs with pancreatic fistulas, intravenous infusion of

Experimental studies on the interrelationship between organs mediated by peptide YY: effect on splanchnic circulation and exocrine pancreas in dogs.

, PYY (1 micrograms/kg) significantly inhibited pancreatic secretion volume and protein output.

Effect of cholecystokinin receptor antagonist on pancreatic responses to exogenous gastrin and cholecystokinin and to meal stimuli.

 antagonism caused little alteration in sham feeding- or urecholine-induced pancreatic protein secretion, but reduced by approximately 60% the pancreatic protein response … meal and virtually abolished the pancreatic responses to duodenal perfusion with amino acids or oleate and to exogenous CCK, but not to 

Effects of leukotriene C4 on pancreatic secretion and circulation in dogs.

In tests with pancreatic secretion induced by

, maximal inhibition by LTC4 occurred at a dose of 1.4 nmol.kg-1.h-1 and reached approximately 70% of the control value for HCO-3 output and 45% for protein output.

Glucagon Inhibition of Cerulein‐Induced Hypertrophy of the Exocrine Pancreas

 is a weak stimulant of pancreatic growth and potentiates the trophic effects of 

, we hypothesized that glucagon might inhibit CCK-induced pancreatic growth.

Mechanical factors regulating gastric emptying examined by the effects of exogenous cholecystokinin and secretin on canine gastroduodenal motility.

It is concluded that the motility parameters that were significantly altered by

 are involved in the control of gastric emptying, while other parameters that remained unchanged play a minor role in the regulating process.

Secretion of Pancreatic Lipase and Colipase from Rat Pancreas

Interaction of cholecystokinin and vasoactive intestinal polypeptide on function of mouse pancreatic acini in vitro.

In isolated mouse pancreatic acini, vasoactive intestinal polypeptide (VIP) and

 potentiated amylase release stimulated by 

 (100‐1000 nM) alone elicited a negligible secretory response, whereas in combination with 

, these agents induced a significantly larger response.

Effects of some drugs and peptide hormones on the responsiveness of the rabbit isolated gall‐bladder to cholecystokinin.

Glucagon, somatostatin, pentagastrin, pancreatic polypeptide, motilin and the Karolinska preparation of

 had no effect on the preparation alone and caused only slight changes when given with 

 exhibited a small cholecystokinin effect when given alone, but considerably inhibited 

Dietary effects on pancreatic exocrine function. Experiments on the isolated perfused rat pancreas.

 (1.8 U/h) is significantly (p less than 0.05 and p less than 0.01, respectively) lower in both experimental … protein and enzyme secretion is diminished only in the secretin plus CCK-stimulated pancreas of rats fed a fat-rich diet.

Secretory effects of cholecystokinins on the isolated perfused porcine pancreas.

We conclude that the effect of these three

 on the endocrine pancreas is without physiological significance, whereas all three are sufficiently potent to play a role in the control of 

Hormonal stimulation of cAMP-dependent protein kinase in rat pancreas.

Incubation of rat pancreas tissue in the presence of

 resulted in an increase of intracellular cAMP and activation of the cAMP-dependent protein kinase.

It is believed that the stimulatory effect of

 contamination of this hormonal preparation.

Cyclic nucleotides, calcium, bicarbonate, and protein secretion in canine pancreatic juice in response to cholecystokinin-pancreozymin.

This study demonstrates the presence of cyclic GMP in the canine pancreatic juice and the dose-dependent stimulation of the secretion of cyclic GMP and cyclic AMP by

Non‐parallel enzyme secretion from rat pancreas in vitro studies.

In experiments on the perfused pancreas, with 8 C u.kg‐1 hr‐1

 (8 ID u.kg‐1) or pilocarpine (15 mg kg‐1) both resulted in a significant change in the enzyme proportions in the juice.

Effect of biliary diversion on exocrine pancreas.

 infusion, a significant decrease in the rate of flow, bicarbonate concentration and amylase output was seen only after choledochojejunostomy.

Non‐parallel enzyme secretion from rat pancreas: in vivo studies.

Stimulation of the protein secretion by I.V.

 (5 CU kg‐1) resulted in a change in the enzyme proportions in pancreatic juice, characterized by decreases in the amylase to chymotrypsinogen and amylase to lipase ratios.

The inhibitory effect of secretin and glucagon on pressure responses to cholecystokinin-pancreozymin in isolated guinea-pig stomach.

 and glucagon in concentrations that did not significantly alter spontaneous activity significantly reduced antral responses to 

, but had no depressive effect on the fundal responses.

 and glucagon in the antral dose-response curve to 

 suggest that the inhibition might be of a non-competitive type.

Bovine pancreatic peptide: action on gastric and pancreatic secretion in dogs.

BPP (2-5 mug/kg-h) inhibited pancreatic water-bicarbonate and protein secretions induced by an infusion of

Different action of hormonal stimulation on the biosynthesis of three pancreatic enzymes.

It was found that chymotrypsinogen, amylase and lipase productions were increased by 63, 26 and 10%, respectively, indicating that repeated

 stimulations could induce "adaptation-like" modifications of the pancreatic enzyme content.

Regulation of amylase release from dispersed pancreatic acinar cells.

, carbamylcholine, or dibutyryl cyclic GMP.

Effect of secretin, glucagon and VIP on gallbladder contraction.

 and glucagon had no effect alone but augmented 

Gallbladder pressure-volume response to gastrointestinal hormones.

 also antagonized the stimulatory response to 

These findings suggest that the regulation of gallbaldder motor function and pressure generation exclusive of neural input, may depend on the interaction of

 and the intraluminal volume of the organ at the time of stimulation.

Interaction of gastrin I, secretin, and cholecystokinin on gallbladder smooth muscle.

These findings suggest that gallbladder motor function may be determined in part by the interaction of

In vitro interactions of gastrointestinal hormones on cyclic adenosine 3':5'-monophosphate levels and amylase output in the rat pancreas.

 was able to exert slight ecbolic effects, and was also able to potentiate the effect of maximal concentrations of 

, caerulein, or the C-terminal octapeptide of pancreozymin.

Pancreozymin, caerulein, and the C-terminal octapeptide of

 inhibited the production of cyclic AMP observed with 

 of VIP, suggesting that the first three peptides were acting at a binding site different from the agonists, but coupled with the same adenylate cyclase.

Early dissociation of protein synthesis and amylase secretion following hormonal stimulation of the pancreas.

The results show that protein synthesis is decreased during the first 15 min after a single injection or infusion of both cholecystokinin

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Possible Interaction: Cholecystokinin and Secretin

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Research Papers that Mention the Interaction