Possible Interaction: Cholecystokinin and Polypeptides

“These findings suggest: (i) CCK secretion is under feedback control by intraduodenal bile acids and to a lesser extent by pancreatic enzymes; (… of zero; (iii) gastrin secretion is feedback controlled via an indirect mechanism probably involving CCK‐induced somatostatin secretion; (iv) release of PP … CCK ; (v) CCK … in humans.”

“However, the observation that physiological concentrations of CCK increase plasma levels of PP , and the finding that CCK receptor blockade selectively attenuates the postprandial increase in plasma PP concentrations support a physiological role for CCK in regulating PP secretion.”

“Plasma pancreatic polypeptide (PP) levels were similarly decreased in five of the six subjects by 19-67% (P = 0.03) in line with the regulation of PP by CCK.”

“The whey protein-enriched … plasma concentrations of cholecystokinin (CCK) at 60 and 75 min (P<0.05), glucagon-like peptide-1 (GLP-1) at ….001), peptide tyrosine–tyrosine (PYY) at 90 and 120 min (P<0.01) and pancreatic polypeptide ( PP ) from 15 to 120 …) compared with maltodextrin carbohydrate.”

“This study provides evidence that CCK exerts an inhibitory effect on gastric acid secretion and plasma gastrin release as well as a stimulatory influence on the release of PP and somatostatin via CCK-A receptors but does not influence directly insulin or glucagon secretion in man.”

“Iv injection of cholecystokinin-8 elicited a small but significant increase in PP concentrations, while iv secretin did not increase PP concentrations at all in healthy subjects.”

“Exogenously administered PP in physiologic doses inhibits cholecystokinin and secretin-stimulated pancreatic secretion in vivo.”

“ICV administration of CCK-8 (1.0, 2.0, 4.0 micrograms) produced a rapid and transient elevation in plasma concentrations of PP.”

“Our results indicate that central administration of CCK-8 selectively elevated plasma PP concentration.”

“The data suggest that in response to bombesin, cadmium has little or no effect on the release of gastrin, but that is exerts a latent effect on the release of both CCK and PP.”