Possible Interaction: Cholecystokinin and Oleic Acid

“ Oleic acid increased the pancreatic secretion of bicarbonate and amylase and the concentrations of secretin and CCK in plasma and provoked gallbladder emptying.”

“Intraduodenal perfusion of phenylalanine and oleic acid increased plasma cholecystokinin (CCK) from a basal level of 0.9 +/- 0.06 to 5.3 +/- 0.9 pM and 7.2 +/- 1.3 pM, respectively.”

“Also, at pH 2.7, oleic acid augmented pancreatic secretion and concentrations of CCK and secretin in plasma.”

“However, oleic acid in addition produced a three-fold increase in plasma CCK and was five times as effective as pH 2.7 in stimulating duodenal flow.”

“A higher concentration (250 μM) of oleic acid or α-linolenic acid can up-regulate CCK mRNA level significantly.”

“Plasma secretin and CCK concentrations also elevated significantly in response to oleic acid , in a dose-related manner (r=0.721 and 0.546, respectively) (P<0.001).”

“We investigated a possible role of endogenous secretin and cholecystokinin (CCK) in inhibition of gastric acid secretion induced by intraduodenal administration of oleic acid in rats.”

“Infusing oleic acid into unadapted rats stimulated CCK secretion and pancreatic exocrine secretion to levels observed with triglycerides in adapted rats.”

“Our results suggest that the satiety response to triolein is produced by the products of triolein digestion and that CCK plays a significant, indispensable role in mediating the satiety response to duodenal delivery of small but not large loads of oleic acid.”

“Plasma CCK bioactivity was significantly increased from the pre-treatment values of 0.8 +/- 0.1pM to 5.1 +/- 1.4pM at 24h after oleic acid treatment.”

“ CCK appears to be directly responsible for the protein and also water response to duodenal infusion of oleic acid , and to be indirectly involved in bicarbonate stimulation.”