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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cholecystokinin
supplement:
Melatonin
Research Papers that Mention the Interaction
“Intraluminal application of melatonin , its precursor: L-tryptophan, leptin or ghrelin dose-dependently increased plasma CCK level.”
Brain-gut axis in the modulation of pancreatic enzyme secretion.“Conversely, prior stimulation of cells with 1 mm melatonin in the absence of extracellular Ca2+ inhibited Ca2+ mobilization in response to a secondary application of CCK‐8 or Tps.”
“In summary, our results show that melatonin releases Ca2+ from intracellular stores and can therefore modulate the responses of the pancreas to CCK‐8.”
Melatonin induces calcium release from CCK‐8‐ and thapsigargin‐sensitive cytosolic stores in pancreatic AR42J cells“Administration of melatonin or its amino-acid precursor to the rats resulted in the significant and dose-dependent rises of melatonin and CCK plasma levels.”
“Moreover, melatonin reduces the duration of cholecystokinin excitomotor effect.”
“These results suggest that, via the central nervous system, melatonin is involved in the modulation of cholecystokinin action on ileal motility.”
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