Possible Interaction: Cholecystokinin and Leucine

“ Leucine at 0.15 kcal/min had no effect on food intake, blood glucose, or antral pressures but also slightly increased plasma cholecystokinin (P < 0.05).”

“Our data demonstrated that stimulation of … jejunum tissue with 10 mM l-leucine , l-isoleucine or BCAAs mix (l-leucine : l-isoleucine : l-valine = 1 : 0.51 : 0.63) for 2 hours significantly increased mRNA expression and protein abundance of T1R1/T1R3 and secretion of CCK (P < 0.05).”

“ Cholecystokinin (CCK) increased the activity of CTSB, cathepsin L , trypsin, chymotrypsin, and caspase 3 in vivo and in vitro and induced redistribution of CTSB to a secretory vesicle-enriched fraction.”

“Contraction induced by 10 nmol/L CCK was inhibited as follows: L 365,260 half maximal inhibition (IC50) = 1 nmol/L greater than L 364,718 (IC50 = 90 nmol/L) greater than proglumide (IC50 = 1 mumol/L).”

“In mouse acini, however, the CCK analogue inhibited [3H]leucine incorporation similar to the effect of CCK-8.”

“The secretory response evoked by CCK-PZ was inhibited by other amino acids (Ala, Asp, Asn, Gly, Ile, Leu , Lys, Met, Phe, Pro, Thr, Trp, Val, in each 20 mM).”

“Stimulation of secretion by cholecystokinin-pancreozymin increased the oxidation of D-glucose, L-alanine and L-leucine.”