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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Cholecystokinin
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“In Huntington's disease, there is reduced binding of GABA and benzodiazepines, dopamine, acetylcholine, glutamate and CCK.”
Receptors in the basal ganglia.“ GABA supplementation increased FI by reducing the mRNA expression levels of FI-inhibiting neuropeptides, such as POMC, leptin, Ghrelin, and CCK , during HS and by increasing the expression of FI-stimulating neuropeptides such as AgRP and NPY.”
Role of gamma-aminobutyric acid in regulating feed intake in commercial broilers reared under normal and heat stress conditions.“Here we show that following bursts of afferent activity, the neuromodulator and satiety peptide cholecystokinin CCK ) shifts the plasticity of GABA synapses in the dorsomedial nucleus of the hypothalamus of male Sprague Dawley rats from long-term depression to long-term potentiation (LTP).”
“The current data provide novel evidence that cholecystokinin shifts the plasticity from long-term depression to long-term potentiation at GABA synapses in the rat dorsomedial nucleus of the hypothalamus.”
“It is indicated that GABA may enhance feed intake by regulating GABA- and cholecystokinin-related genes.”
“Moreover, some evidences show a functional interaction between GABA and CCK in the nervous system.”
“Biochemically, CCK‐4 (0.3 and 1.5 µm), unlike CCK‐8S, enhanced significantly the K+‐stimulated release of [3H]GABA from amygdala slices.”
“RationaleEvidence suggests that γ-aminobutyric acid GABA ) and cholecystokinin (CCK) have opposite roles in the regulation of anxiety.”
“RationaleEvidence suggests that GABA and CCK have opposite roles in the regulation of anxiety.”
“Taken together, these findings indicate that mesolimbic dopamine and CCK exert a respective tonic and phasic inhibition of ventral pallidal GABA release while the antipsychotic activity associated with D1 and D2 receptor antagonists may be explained by their ability to increase ventral striopallidal GABA transmission.”
“7 In summary, we have shown that the CCK‐secreting gut NE cell line STC‐1 expresses functional GABAA receptors and that GABA stimulates CCK release.”
“Thus, GABA is involved in the fine tuning of CCK secretion from the gut NE cell line STC‐1.”
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