Possible Interaction: Cholecystokinin and Chymotrypsin

“Diversion of pancreatic juice from the duodenum stimulates cholecystokinin release and pancreatic enzyme secretion, and intraduodenal administration of trypsin or chymotrypsin inhibits cholecystokinin release and pancreatic secretion.”

“Gastrin, cholecystokinin , and vasoactive intestinal peptide were significantly associated with chymotrypsin in all three statistical models and resulted in a 1.06, 1.98, and 2.74 times higher chymotrypsin level in alcohol-related pancreatitis, respectively.”

“Outputs of trypsin, chymotrypsin , lipase and protein showed a bell-shaped dose response to increasing doses of cholecystokinin , with maximal outputs occurring in response to secretin plus cholecystokinin 0.5 IDU·kg−1·h−1.”

“Overall, duodenal output of chymotrypsin was markedly lower in chronic pancreatitis; however, chymotrypsin output increased in response to both intravenous calcium and CCK-PZ in both groups.”

“In control patients, pancreozymin (CCK) injection led to increases in specific activities of trypsin and chymotrypsin and a decrease in EK but did not change the total EK activities.”

“Cholecystokinin CCK ) increased the activity of CTSB, cathepsin L, trypsin, chymotrypsin , and caspase 3 in vivo and in vitro and induced redistribution of CTSB to a secretory vesicle-enriched fraction.”

“The studies concerning the CCK effects at different incubation temperatures have shown that trypsin and chymotrypsin secretion at 25 degrees C was stimulated by CCK after 15 min, while at 10, 15 and 20 degrees C the stimulatory effects of CCK were observed only after 30 min of incubation.”