Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Cholecystokinin and Choline

drug:

Cholecystokinin

supplement:

Choline

Research Papers that Mention the Interaction

“Substituting choline for NaCl in the extracellular medium elevated basal intracellular Ca2+ concentration and stimulated CCK release.”
Inhibition of Na+/H+ exchange stimulates CCK secretion in STC-1 cells.
The American journal of physiology  •  1998  |  View Paper
“These results suggest that CCK inhibits PC synthesis by inducing both the reduction of choline uptake into acini and the inhibition of CTP: phosphocholine cytidylyltransferase activity.”
[The inhibitory effect of cholecystokinin on phosphatidylcholine synthesis in isolated rat pancreatic acini].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology  •  1991  |  View Paper
“These results indicate that CCK inhibits PC synthesis by inducing both the reduction of choline uptake into acini and the inhibition of CTP:phosphocholine cytidylyltransferase activity.”
Cholecystokinin inhibits phosphatidylcholine synthesis via a Ca(2+)-calmodulin-dependent pathway in isolated rat pancreatic acini. A possible mechanism for diacylglycerol accumulation.
The Journal of biological chemistry  •  1991  |  View Paper
“Substituting choline for NaCl in the extracellular medium elevated basal intracellular Ca2+concentration and stimulated CCK release.”
Inhibition of Na+/H+exchange stimulates CCK secretion in STC-1 cells.
American journal of physiology. Gastrointestinal and liver physiology  •  1998  |  View Paper