Possible Interaction: Cholecystokinin and Calcium Supplement

“In contrast, cholecystokinin-8 (CCK-8) acts by producing a rise in intracellular calcium concentration.”

“Compared to the controls CCK was less effective—the concentration and output of cAMP, bilirubin, K+ and Ca++ were diminished.”

“ Cholecystokinin increases intracellular calcium (Ca2+) in H-PBMC.”

“In vitro imaging reveals that CCK provokes increases in intracellular calcium in vagal afferent terminals as a consequence of a complex interaction between protein kinase A [PKA] and phospholipase C [PLC] transduction mechanisms that open L-type calcium channels and causes endoplasmic reticular [ER] calcium release.”

“Acetylcholine and cholecystokinin induced an increase of internal Ca which in turn activated either only a Cl conductance or both Cl and cationic conductances.”

“Cholecystokinin CCK ) analogs, JMV-180 and OPE, release Ca2+ from intracellular stores and induce oscillations in the concentration of cytosolic Ca2+ ([Ca2+]i), but do not generate a detectable rise in inositol 1,4,5-trisphosphate (InsP3) levels.”

“Low concentrations of these three agonists all induce local Ca(2+)spikes, but in the case of bombesin and CCK these spikes can also trigger global Ca2+ signals.”

“ Cholecystokinin … Ca 2 + oscillations that trigger exocytosis when the cytosolic Ca 2+ concentration exceeds 1 μM. Zymogen granules fused with the plasma membrane maintain their Ω-… an average of 220 s and serve as targets for sequential fusion of granules that are located within deeper layers of the cell.”

“Superfusion of CCK-8S (5-50 nM for 2 min) evoked repetitive Ca increases of several hundred nanomolar in a subpopulation of astrocytes.”

“The corresponding influx of calcium serves to trigger secretion of CCK.”