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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chlorzoxazone
supplement:
Watercress
Research Papers that Mention the Interaction
“ Watercress , a cruciferous vegetable, is known to inhibit the metabolism of several CYP2E1 substrates such as paracetamol and chlorzoxazone.”
Watercress has no Importance for the elimination of ethanol by CYP2E1 inhibition.“The area under the chlorzoxazone plasma concentration‐time curve was significantly increased by 56% (p < 0.05) after watercress ingestion and by 135% (p < 0.001) with isoniazid treatment.”
“These results show that a single ingestion of watercress inhibits the hydroxylation of chlorzoxazone , an in vivo probe for CYP2E1.”
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