Possible Interaction: Chlorthalidone and Potassium

“Plasma potassium concentrations were on average 1 mmol/L lower during the chlorthalidone phase compared to amiloride therapy.”

“During muzolimine treatment, plasma and red cell potassium concentrations remained unchanged, while a significant fall in potassium occured with chlorthalidone.”

“ Potassium loss and TTKG were enhanced during coadministration of CTN , and decreased by PSD. "”

“It was observed a significant reduction of potassium in patients treated with chlorthalidone (4.2 +/- 0.7 to 3.7 +/- 0.4 mEq/L, p < 0.01) that was not observed with the captopril and the thiazide associated.”

“There was a sharp decrease of the average potassium concentration during chlorthalidone and combination treatment periods (average value 3.3 mmol(mEq)/1).”

“ Chlorthalidone caused more potassium wastage than the other diuretics.”

“The chlorthalidone group had lower blood pressure (BP) throughout most of the study, as well as lower total and low-density lipoprotein cholesterol; however, potassium levels were lower and uric acid levels were higher in those taking chlorthalidone.”

“After treatment with chlorthalidone (Hygroton®), 50 mg a day, the excretion of potassium decreased significantly to 83 mEq, suggesting an intracellular deficit of it.”

“100 mg daily of chlorthalidone for a 4-week period produced a significant fall in the plasma potassium concentration and total body potassium content by 16 and 4.2%, respectively.”

“Measurements of potassium status were reviewed in 23 hypertensive patients receiving metoprolol either alone or in combination with chlorthalidone or chlorthalidone plus potassium over an average period of nine months.”

“Thus the use of chlorthalidone plus potassium did not provide adequate prophylaxis against hypokalaemia even in metoprolol recipients.”