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Last Updated: 3 years ago

Possible Interaction: Chlorthalidone and Potassium



Research Papers that Mention the Interaction

Plasma potassium concentrations were on average 1 mmol/L lower during the chlorthalidone phase compared to amiloride therapy.
Drugs  •  2012  |  View Paper
During muzolimine treatment, plasma and red cell potassium concentrations remained unchanged, while a significant fall in potassium occured with chlorthalidone.
European Journal of Clinical Pharmacology  •  2004  |  View Paper
Potassium loss and TTKG were enhanced during coadministration of CTN , and decreased by PSD. "
International journal of clinical pharmacology and therapeutics  •  1999  |  View Paper
It was observed a significant reduction of potassium in patients treated with chlorthalidone (4.2 +/- 0.7 to 3.7 +/- 0.4 mEq/L, p < 0.01) that was not observed with the captopril and the thiazide associated.
Arquivos brasileiros de cardiologia  •  1992  |  View Paper
There was a sharp decrease of the average potassium concentration during chlorthalidone and combination treatment periods (average value 3.3 mmol(mEq)/1).
British medical journal  •  1984  |  View Paper
Chlorthalidone caused more potassium wastage than the other diuretics.
Archives of internal medicine  •  1981  |  View Paper
The chlorthalidone group had lower blood pressure (BP) throughout most of the study, as well as lower total and low-density lipoprotein cholesterol; however, potassium levels were lower and uric acid levels were higher in those taking chlorthalidone.
Hypertension  •  2011  |  View Paper
After treatment with chlorthalidone (Hygroton®), 50 mg a day, the excretion of potassium decreased significantly to 83 mEq, suggesting an intracellular deficit of it.
European Journal of Clinical Pharmacology  •  2004  |  View Paper
100 mg daily of chlorthalidone for a 4-week period produced a significant fall in the plasma potassium concentration and total body potassium content by 16 and 4.2%, respectively.
International journal of clinical pharmacology, therapy, and toxicology  •  1986  |  View Paper
Measurements of potassium status were reviewed in 23 hypertensive patients receiving metoprolol either alone or in combination with chlorthalidone or chlorthalidone plus potassium over an average period of nine months.
Thus the use of chlorthalidone plus potassium did not provide adequate prophylaxis against hypokalaemia even in metoprolol recipients.
Scottish medical journal  •  1983  |  View Paper
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