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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chlortetracycline
supplement:
Citric Acid
Research Papers that Mention the Interaction
“Following oral chlortetracycline intake, low dietary calcium or citric acid addition to the diet produced increased chlortetracycline serum concentrations.”
Influence of dietary citric acid and calcium on the bioavailability of orally administered chlortetracycline in piglets.“When the dose of chlortetracycline was increased to 50 mg/kg, addition of citric acid caused higher serum levels the first two hours after feeding.”
“Cultivation of sporulating cells with citric acid highly increased the binding of chlortetracycline on or in the cells.”
Spores of microorganisms X. Interference of tetracycline antibiotics with sporogenesis of Bacilli“The administration of citric acid-CTC significantly increased the mean serum concentration of CTC and the fraction of the dose absorbed.”
“The citric acid-CTC mixture also produced significantly higher elimination (Kel) and distribution (K12) rate constants for CTC.”
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