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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chlortetracycline
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Addition of calcium and ATP to inside out vesicles in the presence of chlortetracycline increased the chlortetracycline fluorescence as a function of time following an initial delay.”
“ Chlortetracycline is a divalent metal chelator which increases its fluorescence when bound to calcium in the presence of a membrane.”
Studies on the Ca2+ transport mechanism of human erythrocyte inside-out plasma membrane vesicles. V. Chlortetracycline fluorescence.“It is detected as an increase of CA2+ binding inside the SR with chlorotetracycline and as a "hyperpolarization" with potential-sensitive dyes, while no transient change of myoplasmic [Ca2+]free is detected with arsenazo III.”
Fluorescence and differential light absorption recordings with calcium probes and potential-sensitive dyes in skinned cardiac cells.“Reducing dietary calcium from 0.8 to 0.4% significantly increased serum levels of CTC and OTC.”
“Also, it was demonstrated that chlorotetracycline addition to mitochondria which had been loaded previously with 45 Ca resulted in a rapid efflux of the accumulated 45 Ca.”
“Fluorescence of chlorotetracycline increased in the suspension of liposomes loaded with Ca+2 due to the formation of Ca+2-chlorotetracycline-phospholipid membrane complex.”
“Reduction of the dietary calcium level from 1.18 to 0.18% resulted in more than a two-fold increase in serum levels of oxytetracycline (OTC) or chlortetracycline (CTC).”
“Fluorescence resonance energy transfer (FRET) analysis indicated reduced levels of intracellular calcium are associated with CTC uptake and toxicity.”
“These findings support a model in which CTC uptake through roots leads to reductions in levels of intracellular calcium due to chelation.”
Toxicity and reductions in intracellular calcium levels following uptake of a tetracycline antibiotic in Arabidopsis.“Excess calcium in the medium somewhat stimulated dipicolinic acid synthesis in the presence of chiortetracycline and in the controls.”
“Possible factors are complexing with calcium and other metallic ions and enhancement of chlortetracycline stability.”
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