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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Chlorpropamide and Leucine

supplement:

Leucine

Research Papers that Mention the Interaction

These authors showed that, whereas the amino acid, L-leucine , induced only a modest rise in peripheral plasma insulin concentration in normal subjects, the response was dramatically enhanced by pre-treatment of these subjects with chlorpropamide.
Postgraduate medical journal  •  1967  |  View Paper
leucine to healthy … either chlorpropamide or tolbutamide (2, 3), and also to some patients with functioning islet cell tumors of the pancreas (4), increments in plasma leucine … plasma insulin and decreases in blood glucose that were significantly greater than those observed in healthy subjects not pretreated with sulfonylurea drugs.
The Journal of clinical investigation  •  1966  |  View Paper