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“These authors showed that, whereas the amino acid, L-leucine , induced only a modest rise in peripheral plasma insulin concentration in normal subjects, the response was dramatically enhanced by pre-treatment of these subjects with chlorpropamide.”
“… leucine to healthy … either chlorpropamide or tolbutamide (2, 3), and also to some patients with functioning islet cell tumors of the pancreas (4), increments in plasma leucine … plasma insulin and decreases in blood glucose that were significantly greater than those observed in healthy subjects not pretreated with sulfonylurea drugs.”