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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chlorpropamide
supplement:
Glucose
Research Papers that Mention the Interaction
“Since lipolysis as well as re-esterification of FFA is accelerated by glucose, present data would indicate that chlorpropamide primarily interferes with the glucose metabolism or the stimulatory action of glucose on the two pathways of the triglyceride-FFA cycle.”
Chlorpropamide and lipid metabolism of rat and human adipose tissue in vitro.“We conclude that inhibition of endogenous glucose production during chronic chlorpropamide therapy is an important mechanism for the lowering of FPG and that enhanced insulin secretion is the reason for the major part of this inhibition.”
“The reductions in phosphorylase a activity after treatment with chlorpropamide were more than sufficient to explain the accompanying decreases in hepatic glucose production.”
Inhibition of hormonal activation of hepatic phosphorylase by chlorpropamide: evidence for an intracellular site of drug action.“of chlorpropamide for four days decreased the ability of the dogs to dispose of a glucose load , and the deterioration in glucose tolerance was accompanied by a marked suppression of the plasma insulin response.”
“ Diabinese monotherapy reduced bilirubin levels, while combined therapy reduced glucose , ALP, AST, and ALT levels more than single therapy.”
Effect of combined therapy of diabinese and nicotinic acid on liver enzymes in rabbits with dithizone-induced diabetes
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