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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Chlorpromazine
supplement:
Ubiquinone
Research Papers that Mention the Interaction
“ CoQ10 prevented significantly the decrease in VMRT and the disturbance of mitochondrial function induced by CPZ , but did not prevent the hypotensive effect of CPZ.”
Mechanism of chlorpromazine-induced arrhythmia -- arrhythmia and mitochondrial dysfunction.“Coincubation of the cultures with CPZ and CoQ led to a dose-dependent increase in ATP contents and beating rates.”
A protective action of coenzyme Q10 on chlorpromazine-induced cell damage in the cultured rat myocardial cells.“In this study, we … treatment with taurine and coenzyme Q10 (COQ-10), compounds with steroidogenic-gonadotropin … attenuate the negative impacts of chlorpromazine on steroidogenic, gonadotropin, thyroid and HPA-axis hormones, dopamine levels, catalepsy behavior and neuronal … and pituitary gland in the preventive and reversal treatments in male Wister rats.”
“Taurine and COQ-10 reduced the changes in thyroid hormones, corticosterone release, histological distortions of the hypothalamus and the pituitary gland of chlorpromazine-treated rats.”
Taurine and coenzyme Q10 synergistically prevent and reverse chlorpromazine-induced psycho-neuroendocrine changes and cataleptic behavior in rats.
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