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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chlorpromazine
supplement:
Riboflavin
Research Papers that Mention the Interaction
“Of these drugs, boric acid and its derivatives as well as the antipsychotic agent, chlorpromazine , have been shown to promote riboflavinuria in both animals and man.”
Drugs that promote renal excretion of riboflavin.“The psychotropic drug, chlorpromazine , over a wide dose range, exerted an inhibitory effect on both incorporation of riboflavin into FAD and the utilization of FAD for incorporation into covalently bound flavoenzymes in liver, cerebrum, and cerebellum.”
Inhibition by chlorpromazine of thyroxine modulation of flavin metabolism in liver, cerebrum and cerebellum.“It is concluded that significant riboflavin depletion occurs following treatment with low doses of chlorpromazine , both in animals fed a normal diet and in animals fed a riboflavin-deficient diet, particularly during the early stages of deficiency.”
“Thus, chlorpromazine treatment accelerated urinary riboflavin loss and accelerated tissue depletion of FAD levels during dietary riboflavin deficiency.”
“Abstract Chlorpromazine inhibits the incorporation of riboflavin into flavin adenine dinucleotide and flavins bound covalently to proteins in vivo in rat liver.”
“ Chlorpromazine can also form complexes with FMN and rhodamine B11,12.”
Evidence of Complex Formation between Chlorpromazine and Different Xanthene Dyes
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