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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chlorpromazine
supplement:
Progesterone
Research Papers that Mention the Interaction
“In …, CPZ + PRO caused a significant reduction in the mRNA expression levels of M1‐markers (iNOS, CD86, MHC‐II and TNF‐&agr;) in the corpus callosum region, whereas the expression of M2‐markers (Trem‐2, CD206, Arg‐1 and TGF‐&bgr;) was significantly increased, in comparison to CPZ mice.”
Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone‐induced demyelination mouse model“The aim of the study was to investigate whether oral contraceptives such as ethinyloestradiol and progesterone enhance the absorption of chlorpromazine by means of inhibiting P-glycoprotein (P-gp) and if this effect is mainly due to ethinyloestradiol or progesterone or their combination.”
“ Chlorpromazine , which interferes with the secretion of gonadotropins in vivo, produced a significant inhibition of progesterone and testosterone secretion as a result of the cytotoxic effects of the drug.”
Pig Leydig cell culture: a useful in vitro test for evaluating the testicular toxicity of compounds.
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