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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chlorpromazine
supplement:
Potassium
Research Papers that Mention the Interaction
“The extent of inhibition by chlorpromazine in norepinephrine-induced contraction was much greater than that in 80 mM Potassium sup + -induced contraction.”
Direct Inhibitory Effect of Chlorpromazine on Smooth Muscle of the Porcine Pulmonary Artery“The results showed that chlorpromazine induced the passive permeability of mitochondrial membrane to potassium.”
“ Chlorpromazine (8×10-6–3×10-5 M), imipramine, and quinidine (5×10-5–10-4 M) prolonged the relaxation phase of potassium induced contractures in single skeletal muscle fibres of the frog without affecting the maximum tension amplitude.”
“It has been shown that CPZ in bacteriostatic concentration probably changes the transport of potassium through the bacterial membrane in the same manner as described for mammalian muscle tissue.”
Experiments to Illustrate The Effect Of Chlorpromazine On The Permeability Of The Bacterial Cell Wall“Malonate (1 mM), pentobarbital (0.5 mM), and … potassium uptake, and phenobarbital (0.5 mM), chlorpromazine (0.01 mM), atropine (1 mM), and procaine (0.1 mM), which have no effect on … 3.6 mM potassium on respiration and markedly reduce the large stimulatory effect of 60 mM potassium.”
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