Possible Interaction: Chlorpromazine and Niacin

“In the presence of saturating amounts of nicotinamide, chlorpromazine increased rather than decreased the methylation of nicotinamide.”

“As can be seen, the elevated level of DPN in rat liver, brought about by nicotinamide , is prolonged by preinjection of chlorpromazine.”

“I t has been difficult to carry out a study of the effect of chlorpromazine on the DPN response to nicotinamide administration in hypophysectomized animals, since the combination of chlorpromazine and nicotinamide , in the concentrations used in normal animals, was lethal to hypophysectomized animals.”

“… nicotinamide, … chlorpromazine or reserpine, as shown by Burton et aZ.l The important work of Brodie and his group at the National Institutes of Health, Public … co-workers of a biochemical action common to chlorpromazine and reserpine was of considerable interest to us and, we felt, warranted further investigation.”