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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chlorpromazine
supplement:
Methionine
Research Papers that Mention the Interaction
“The bulk volume of the molecules cannot completely account for the 4.5% expansion of the erythrocyte membrane area that is known to occur in the presence of 2·10−5 M chlorpromazine.”
The membrane concentration of a local anesthetic (chlorpromazine).“Tested against calcium channel blocking agents, L-methionine reduces the inhibition caused by diltiazem and chlorpromazine but not that caused by TMB 8 or verapamil.”
Effect of L-methionine on contractile response, calcium influx and calcium channel blocking agents in the rat aorta.“Especially the effect of chlorpromazine upon the induction is enhanced by methionine or by a combination of tryptophan and methionine.”
“Inhibition of methionine transport by chlorpromazine is time dependent and concentration dependent.”
“Lineweaver-Burk plots constructed from 15-min uptake values of methionine in the presence of various concentrations of chlorpromazine indicate that 5 times 10-5 M-chlorpromazine competitively inhibits methionine uptake in blastocysts, while 10-4 M-chlorpromazine non-competitively inhibits transport.”
“Thus, chlorpromazine inhibits 90 per cent at 2 × 10 −4 M , at which concentration its sulphoxide has no effect.”
Action of some phenothiazine derivatives on the respiratory chain.
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