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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chlorpromazine
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“However, CPZ administration to rats treated sub-chronically with Fe showed increased brain CAT activity after 2 or 4 h, as compared to control values.”
“The hypothesis tested is that Fe administration leads to a response in rat brain modulating the effects of later oxidative challenges such as chlorpromazine (CPZ) administration.”
Iron overload prevents oxidative damage to rat brain after chlorpromazine administration“Iron chelators, U74500A, desferrioxamine and to a lesser extent 1,10-phenanthroline and chlorpromazine could displace iron from melanin.”
“The binding of iron to melanin is dependent on pH and the … Iron dictators, U74500A, desferrioxamme, and to less extent 1,10‐phenanthroline and chlorpromazine , but not the Parkinson‐inducing neurotoxin, 1‐methyl‐4‐…,2,3,6‐tetrahydropyridine, can inhibit the binding of iron to melanin and … lipid peroxidation.”
“ Chlorpromazine showed some ability to inhibit iron ion-dependent hydroxyl radical formation.”
Characterization of the potential antioxidant and pro-oxidant actions of some neuroleptic drugs.
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