supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
drug:
Chlorpromazine
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“However, CPZ administration to rats treated sub-chronically with Fe showed increased brain CAT activity after 2 or 4 h, as compared to control values.”
“The hypothesis tested is that Fe administration leads to a response in rat brain modulating the effects of later oxidative challenges such as chlorpromazine (CPZ) administration.”
Iron overload prevents oxidative damage to rat brain after chlorpromazine administration“Iron chelators, U74500A, desferrioxamine and to a lesser extent 1,10-phenanthroline and chlorpromazine could displace iron from melanin.”
“The binding of iron to melanin is dependent on pH and the … Iron dictators, U74500A, desferrioxamme, and to less extent 1,10‐phenanthroline and chlorpromazine , but not the Parkinson‐inducing neurotoxin, 1‐methyl‐4‐…,2,3,6‐tetrahydropyridine, can inhibit the binding of iron to melanin and … lipid peroxidation.”
“ Chlorpromazine showed some ability to inhibit iron ion-dependent hydroxyl radical formation.”
Characterization of the potential antioxidant and pro-oxidant actions of some neuroleptic drugs.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback