Possible Interaction: Chlorpromazine and Glycine

“Hemolysis experiments indicated that glycine (20 mM) remarkably suppressed the chlorpromazine (CPZ)-induced osmotic permeability enhancing effect in rabbit erythrocytes.”

“The kinetic studies in isotonic suspensions of erythrocytes indicated that glycine decreased the hemolytic activity of CPZ , and it was suggested that glycine molecules possibly inhibited penetration of CPZ into the cell membranes.”

“Although CPZ potentiated the effect of Gly on the level of DA, it inhibited the Gly-related increase in FAA levels, apparently through the blockade of DA receptors.”

“Although CPZ potentiated the effect of Gly on the level of DA, it inhibited the Gly-related increase in FAA levels, apparently through the blockade of DA receptors.”

“Abstract A single intravenous injection of chlorpromazine or octoclothepine (10 mg/kg) enhanced the in vivo incorporation of labeled glycine into brain and liver proteins.”

“Analysis using a 5-doxyl stearic acid (DS) spin probe indicated that the hydrophobic region near the surface of the liposomes containing glycine was restricted in motion by the addition of CPZ.”

“It was shown that glycine could reduce the liposome lytic action of CPZ , without decreasing its surface activating action.”

“The perturbing action of CPZ on the 16-DS-labeled liposomes was weakened by the presence of glycine , suggesting the reduced penetrance of undissociated CPZ molecules into the center of the bilayers (lipid core).”

“Thus, glycine presumably prevented CPZ molecules incorporated into the liposome surface from transferring into the lipid core by its packing effect.”