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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chlorpromazine
supplement:
Glucose
Research Papers that Mention the Interaction
“In human RBC membrane chlorpromazine decreases the penetration of D(+) glucose.”
The effect of chlorpromazine on monosaccharide transport in fish erythrocytes.“ CPZ accelerated glucose exit at concentrations between 1 × 10 −5 and 2 × 10 −5 M at 36° but at higher concentrations inhibited transfer.”
“ CPZ affects the entry of glucose into erythrocytes in a biphasic manner similar to its effect on exit but at all concentrations it accelerates the penetration of ethylidene glucose which enters by diffusion.”
“ CPZ , trifluoperazine, prochlorperazine, promazine and promethazine were found to inhibit glucose exit approximately in the order of their chemotherapeutic potency.”
“It is suggested that at low concentrations CPZ accelerates the movement of the glucose carrier within the membrane by effects on its charge environment.”
“However, HCPZ decreased whole-body glucose infusion rates in hyperinsulinemic clamped states, but not whole-body glucose uptake.”
Chlorpromazine exacerbates hepatic insulin sensitivity via attenuating insulin and leptin signaling pathway, while exercise partially reverses the adverse effects.“EGTA (2 mM), chlorpromazine (200 microM) and lanthanum (3 mM) decreased the glucose release promoted by external Ca2+ absence.”
“The effects of glucose and tolbutamide on insulin secretion were inhibited by low concentrations of chlorpromazine (0.005 mM–0.01 mM) and were stimulated by high concentrations (0.5 mM–1 mM).”
“Abstract Chlorpromazine lowered the ratio of plasma insulin to blood glucose in adrenalectomized rats fed a glucose load.”
“ Chlorpromazine pretreatment (10 mg/kg, ip) reduced the capacity of the animals to secrete insulin in response to intravenously administered glucose and tolbutamide.”
“administration of CPZ promotes the absorption of both 3-MG and glucose from the peritoneal cavity.”
“The results indicate that the adrenals are necessary for chlorpromazine-induced hyperglycemia and that chlorpromazine impairs peripheral utilization of glucose.”
“ Chlorpromazine exerts a progressive inhibitory activity (at 0.3–0.6 mM) on the respiration of brain cortex in presence of either glucose , fructose, pyruvate, or L-glutamate.”
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