Possible Interaction: Chlorpromazine and Gamma-Aminobutyric Acid

“At doses above 1 microM trifluoperazine, chlorpromazine and thioridazine blocked GABA currents in a non-competitive fashion decreasing the maximal transmitter response without altering the half-maximal effective concentration.”

“The prolonged cardiovascular depression in response to GABA could be attenuated by subsequent administration of picrotoxin and bicuculline as well as by alpha-methyltyrosine, corynanthine, chlorpromazine and tripelennamine.”

“ Chlorpromazine , at a dose which decreased spontaneous activity, enhanced the AOAA‐induced GABA accumulation in the cingulate cortex, suggesting that drug‐induced sedation is not necessarily associated with decreased GABA synthesis.”

“Either rapid iv injection or infusion of GABA in doses of 1 to 100 mg in rats significantly decreased serum prolactin levels, which were previously elevated by pretreatment with monoiodotyrosine perphenazine, chlorpromazine , haloperidol, or sulpiride.”

“ Chlorpromazine had the highest inhibitory effect on GABA uptake and phthoracizine--the lowest.”

“In the presence of chlorpromazine the amount of GABA in the synaptosomes increased, but the efflux and influx of GABA were slightly reduced.”

“Considerable inhibition of the uptake of GABA by brain slices was observed with glutamic acid, imipramine, chlorpromazine , procaine, xylocaine or picrotoxin but not with acetylcholine, prostigmine, norepinephine, dopamine, chloral hydrate, chloretone, pentylentetrazol or methionine sulphoximine.”