Possible Interaction: Chlorpromazine and Dextroamphetamine

“ Chlorpromazine treatment significantly increased the frequency of self-administration of cocaine, pipradrol, phenmetrazine, d-amphetamine and methylphenidate.”

“The pecking response induced by d-amphetamine was antagonized by chlorpromazine , haloperidol or bulbocapnine indicating that this pecking response was caused by dopaminergic receptor stimulation.”

“Against the suppressant effect of chlorpromazine , protection was given by d-amphetamine , scopolamine and chlordiazepoxide.”

“Dose combinations of 0.3 mg/kg chlorpromazine with D-amphetamine (0.1, 0.3, 1.0 mg/kg) illustrated the antagonistic effects of the two drugs.”

“The rate-suppressive effect on high response rates of 1.0 mg/kg D-amphetamine was abolished when given together with 0.3 mg/ kg chlorpromazine.”

“Abstract— The development of sensitization to the ambulation‐increasing effect of (+)‐amphetamine (2·5 mg kg−1) was found … dose‐dependently inhibited when 1 or 2 mg kg−1 chlorpromazine was administered concomitantly, and the sensitization to (+)‐amphetamine was almost completely suppressed when … with 4 mg kg−1 chlorpromazine.”

“ CO-chlorpromazine and CO-d-amphetamine combinations often produced greater than additive response-rate suppression, although differences from additivity did not reach statistical significance.”

“On cells excited by DA, surfused DEX (5.5 X 10(-7)M) caused an excitation that could be blocked by chlorpromazine (0.5-1 X 10(-6)M) or haloperidol (0.5-1 X 10(-6)M).”

“Thus, trifluoperazine, haloperidol, fluphenazine, chlorpromazine and thioridazine, but not clozapine, decreased d-amphetamine-induced control of discriminative performance.”

“The antagonism was selective, however, in that the error-increasing effect of d-amphetamine was augmented by chlorpromazine.”

“When a small dose of chlorpromazine , which was ineffective when given alone, was administered in combination with d-amphetamine , the rate-decreasing effect was antagonized.”

“1 The ability of chlorpromazine to antagonize the effects of iontophoretic application of (+)‐amphetamine to single neurones in the medulla and lower pons of anaesthetized rats has been studied.”

“2 Chlorpromazine , administered systemically or iontophoretically, consistently and specifically antagonized the excitatory actions of (+)‐amphetamine , but not those of noradrenaline on the same neurone.”

“3 It is concluded that chlorpromazine reduces the effect of (+)‐amphetamine by a presynaptic mechanism.”

“4 (+)‐Amphetamine did not mimic the prolonged inhibitory response of some neurones to noradrenaline but often excited these neurones and chlorpromazine blocked these excitatory responses to (+)‐amphetamine.”