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Last Updated: 2 years ago

Possible Interaction: Chlorpromazine and Dextroamphetamine

Research Papers that Mention the Interaction

Chlorpromazine treatment significantly increased the frequency of self-administration of cocaine, pipradrol, phenmetrazine, d-amphetamine and methylphenidate.
Psychopharmacologia  •  2004  |  View Paper
The pecking response induced by d-amphetamine was antagonized by chlorpromazine , haloperidol or bulbocapnine indicating that this pecking response was caused by dopaminergic receptor stimulation.
European journal of pharmacology  •  1975  |  View Paper
Against the suppressant effect of chlorpromazine , protection was given by d-amphetamine , scopolamine and chlordiazepoxide.
Psychopharmacologia  •  2004  |  View Paper
Dose combinations of 0.3 mg/kg chlorpromazine with D-amphetamine (0.1, 0.3, 1.0 mg/kg) illustrated the antagonistic effects of the two drugs.
The rate-suppressive effect on high response rates of 1.0 mg/kg D-amphetamine was abolished when given together with 0.3 mg/ kg chlorpromazine.
Psychopharmacologia  •  2004  |  View Paper
Abstract— The development of sensitization to the ambulation‐increasing effect of (+)‐amphetamine (2·5 mg kg−1) was found … dose‐dependently inhibited when 1 or 2 mg kg−1 chlorpromazine was administered concomitantly, and the sensitization to (+)‐amphetamine was almost completely suppressed when … with 4 mg kg−1 chlorpromazine.
The Journal of pharmacy and pharmacology  •  1993  |  View Paper
CO-chlorpromazine and CO-d-amphetamine combinations often produced greater than additive response-rate suppression, although differences from additivity did not reach statistical significance.
Neurotoxicology and teratology  •  1989  |  View Paper
On cells excited by DA, surfused DEX (5.5 X 10(-7)M) caused an excitation that could be blocked by chlorpromazine (0.5-1 X 10(-6)M) or haloperidol (0.5-1 X 10(-6)M).
European journal of pharmacology  •  1981  |  View Paper
Thus, trifluoperazine, haloperidol, fluphenazine, chlorpromazine and thioridazine, but not clozapine, decreased d-amphetamine-induced control of discriminative performance.
Pharmacology Biochemistry and Behavior  •  1980  |  View Paper
The antagonism was selective, however, in that the error-increasing effect of d-amphetamine was augmented by chlorpromazine.
When a small dose of chlorpromazine , which was ineffective when given alone, was administered in combination with d-amphetamine , the rate-decreasing effect was antagonized.
Journal of the experimental analysis of behavior  •  1980  |  View Paper
1 The ability of chlorpromazine to antagonize the effects of iontophoretic application of (+)‐amphetamine to single neurones in the medulla and lower pons of anaesthetized rats has been studied.
2 Chlorpromazine , administered systemically or iontophoretically, consistently and specifically antagonized the excitatory actions of (+)‐amphetamine , but not those of noradrenaline on the same neurone.
3 It is concluded that chlorpromazine reduces the effect of (+)‐amphetamine by a presynaptic mechanism.
4 (+)‐Amphetamine did not mimic the prolonged inhibitory response of some neurones to noradrenaline but often excited these neurones and chlorpromazine blocked these excitatory responses to (+)‐amphetamine.
British journal of pharmacology  •  1979  |  View Paper
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