Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Chlorpromazine and Cocaine

supplement:

Cocaine

Research Papers that Mention the Interaction

Chlorpromazine (0.25–1.0 mg/kg), haloperidol (0.25, 0.5 mg/kg), and physostigmine (0.04, 0.08 mg/kg), administered before the third amphetamine or cocaine injection , blocked the motor stereotypies and hyperactivity.
Psychopharmacology  •  2004  |  View Paper
Chlorpromazine treatment significantly increased the frequency of self-administration of cocaine , pipradrol, phenmetrazine, d-amphetamine and methylphenidate.
Psychopharmacologia  •  2004  |  View Paper
Intravenous administration of 0.5 and 2.0 mg/kg cocaine to rats in which the endogenous release of CRF was blocked by chlorpromazine , morphine, and pentobarbital elicited a significant increase in plasma corticosterone concentrations.
Peptides  •  1987  |  View Paper
When monkeys were pretreated with chlorpromazine (0.03–5.6 mg/kg, im) before a cocaine self-injection session, small doses marginally increased responding and larger doses exerted a suppressive effect.
Canadian journal of physiology and pharmacology  •  1977  |  View Paper
These data indicate that chlorpromazine may nonspecifically antagonize the behavioral effects of cocaine ; whereas, atropine may enhance these effects.
Pharmacology Biochemistry and Behavior  •  1975  |  View Paper