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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chlorpromazine
supplement:
Cocaine
Research Papers that Mention the Interaction
“ Chlorpromazine (0.25–1.0 mg/kg), haloperidol (0.25, 0.5 mg/kg), and physostigmine (0.04, 0.08 mg/kg), administered before the third amphetamine or cocaine injection , blocked the motor stereotypies and hyperactivity.”
Disruption of primate social behavior by d-amphetamine and cocaine: Differential antagonism by antipsychotics“ Chlorpromazine treatment significantly increased the frequency of self-administration of cocaine , pipradrol, phenmetrazine, d-amphetamine and methylphenidate.”
“Intravenous administration of 0.5 and 2.0 mg/kg cocaine to rats in which the endogenous release of CRF was blocked by chlorpromazine , morphine, and pentobarbital elicited a significant increase in plasma corticosterone concentrations.”
Cocaine induced secretion of ACTH, beta-endorphin, and corticosterone“When monkeys were pretreated with chlorpromazine (0.03–5.6 mg/kg, im) before a cocaine self-injection session, small doses marginally increased responding and larger doses exerted a suppressive effect.”
“These data indicate that chlorpromazine may nonspecifically antagonize the behavioral effects of cocaine ; whereas, atropine may enhance these effects.”
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