Possible Interaction: Chlorpromazine and Calcium Supplement

“Calmodulin (CaM) antagonists, W-7 and W-5, chlorpromazine and haloperidol, especially W-7 inhibited 125I-bovine TSH binding to human and porcine thyroid receptors dose-dependently in the presence of calcium ion.”

“An increase in susceptibility of neuroblastoma cells to calcium was inhibited when the cells were treated with hypothermia, diphenylhydantoin, chlorpromazine or pentobarbital; all of these treatments affect membrane permeability to calcium or membrane-associated cell metabolism.”

“Diphenylhydantoin and chlorpromazine were found to have positive effects only when they were administered before the addition of calcium.”

“ Chlorpromazine affected both influx and efflux of calcium.”

“The calcium induced increase in ATPase and the rate of calcium uptake of the vesicular fragments of sarcoplasmic reticulum isolated from rabbit skeletal muscle are reduced by reserpine, prenylamine, chlorpromazine and imipramine.”

“The results suggest that chlorpromazine negatively modulates the store‐operated Ca2+ entry activated subsequent to PLC activation.”

“In the presence of inorganic phosphate (P(i)), Ca2+ -induced MPT was suppressed by BSA, L-carnitine, and chlorpromazine , an inhibitor of phospholipase A2.”

“Acridine orange and disubstituted chlorpromazine CPZ ) derivatives lowered Ca2+ and Mg2+ binding and membrane polarization in the simplest biological membrane (E. coli), as revealed by reactor neutron activation analysis.”

“ Chlorpromazine , which has an antagonistic action towards calmodulin, also suppressed the increases of calcium and ALP in the tooth germ.”

“In addition, TFP and CPZ produced a dose-related decrease in the observed intracellular calcium space in duodenal tissue and reduced calcium uptake into isolated enterocytes.”

“At 10(-5) M, shortening of the isometric relaxation and decrease in R2 = (+dF.dt-1max)/(-dF.dt-1max) suggest that chlorpromazine also diminishes myofilament Ca++ sensitivity.”