Possible Interaction: Chlorpromazine and Adrenocorticotropic Hormone

“Patients receiving ACTH and chlorpromazine had significantly fewer episodes of vomiting (p less than 0.01) and shorter periods of nausea (p less than 0.02) than patients receiving placebo and chlorpromazine.”

“The present data indicate that chlorpromazine promotes the secretion of both prolactin and ACTH.”

“Preliminary administration of centrally acting neurotropic drugs (amytal, chlorpromazine , muscarine-l ike and nicotine-like cholinolytics methyldiazine and adiphcnine) to dogs diminishes conditionedreflex hypersecretion of ACTH as judged from the level of 17-hydroxycorticosteroids in the blood.”

“Although amphetamine and ACTH produced no consistent effects, chlorpromazine caused a marked decrease in threshold.”

“ Chlorpromazine and haloperidol suppressed basal ACTH secretion and inhibited the ME extract-induced release.”

“Subcutaneous injection of chlorpromazine to rats caused a lesser increase in body temperature and a higher content of the corticotropin-releasing factor (CRF) in the hypothalamus and the ACTH in the hypophysis under conditions of exogenous hyperthermia.”

“Summary Chlorpromazine inhibits the ACTH and cyclic AMP-stimulated corticosterone synthesis, in vitro , in the quartered rat adrenal glands without greatly affecting the basal production of corticosterone.”

“It has been reported that production of ACTH is elevated /4,5/ or depressed /3/ when chlorpromazine is administered to the animals.”

“ Chlorpromazine (3 x 10(-4)M) prevents the stimulation of adenyl cyclase activity in thyroid membranes produced by thyrotropin and prostaglandin, ACTH stimulation of adenyl cyclase in adrenal tissue, and glucagon- and epinephrine-stimulation of adenyl cyclase activity in liver.”

“Psychopharmacological agents such as reserpine, chlorpromazine , monoamine oxidase inhibitors, and amphetamine have profound effects on ACTH secretion.”