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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Chlorothiazide and Potassium



Research Papers that Mention the Interaction

Chlorothiazide , 500 mg, caused less sodium and chloride output with similar potassium loss.
Clinical pharmacology and therapeutics  •  1987  |  View Paper
This suggests that an extrarenal action of chlorothiazide on the cell membrane promotes cellular uptake of potassium.
Mineral and electrolyte metabolism  •  1982  |  View Paper
Consequently, if the cellular potassium is further depressed owing to diarrhoea and vomiting or to administration of drugs that cause loss of potassium-such as those of the chlorothiazide group or the steroids-there is a risk that the patient's condition will deteriorate and even end fatally.
Schweizerische medizinische Wochenschrift  •  1967  |  View Paper
Chlorothiazide ( 6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1, 1-dioxide ) markedly alters the renal excretion of sodium, chloride, and potassium and is a potent diuretic.
Journal of the American Medical Association  •  1960  |  View Paper
Chlorothiazide also promoted the excretion of potassium , whereas meralluride had little effect on potassium excretion.
The American journal of medicine  •  1959  |  View Paper
Chlorothiazide caused an inhibition of distal tubular sodium reabsorption and an enhancement of potassium secretion in the distal nephron.
The American journal of physiology  •  1962  |  View Paper
The latter two can also operate to block the potassium wastage of chlorothiazide.
Circulation  •  1962  |  View Paper
The fourth is chlorothiazide , which can, in addition to a desirable hypotensive effect, cause diuresis and quickly deplete the body of potassium.
Journal of the American Medical Association  •  1958  |  View Paper