Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Chlorothiazide and Calcium Supplement

Research Papers that Mention the Interaction

When CTZ was given at a high dosage (130 mg/kg of body weight), urinary calcium excretion was significantly (P < 0.04) higher than baseline values.
American journal of veterinary research  •  1992  |  View Paper
Chlorothiazide reduced the urinary calcium excretion level in two of six patients to the normal range.
Australian and New Zealand journal of medicine  •  1986  |  View Paper
Both chlorothiazide and parathyroid hormone enhance the transport of calcium in this segment.
The American journal of physiology  •  1979  |  View Paper
The results are consistent with the idea that chlorothiazide enhances the ratio of calcium to sodium reabsorptions and that this tendency for absolute hypocalciuria can be overridden by a large natriuretic response to the drug.
Under the influence of chlorothiazide , there was a strong linear correlation between the changes in the excretion of calcium and sodium.
Kidney international  •  1976  |  View Paper
A decrease in urinary calcium has been related to the oral administration of chlorothiazide and...
The New England journal of medicine  •  1971  |  View Paper
The fraction of sodium remaining at the distal tubule rose from 4.0 +/- 1.4 to 10.0 +/- 1.4% while that of calcium decreased from 10.2 +/- 1.1 to 7.6 +/- 1.2% following administration of chlorothiazide.
Canadian journal of physiology and pharmacology  •  1982  |  View Paper
CTZ , acting from the lumen, enhanced net calcium (P less than 0.01) and reduced net sodium (P less than 0.01) reabsorption.
The American journal of physiology  •  1978  |  View Paper
Chlorothiazide alone significantly increased fractional excretion of sodium (0.5 +/- 0.3-5.6 +/- 0.3%) and calcium (0.74 +/- 0.18-1.4 +/- 0.24%).
The American journal of physiology  •  1975  |  View Paper
The decrease in clearance of diffusible calcium seen after intravenous chlorothiazide differs from the calciuria observed after the administration of mercurials and acetazolamide.
The results demonstrate that intravenous chlorothiazide causes a significant increase in both phosphorus and uric acid clearances and an equivocal decrease in the clearance of diffusible calcium.
Metabolism: clinical and experimental  •  1965  |  View Paper