Possible Interaction: Chloroquine and Vitamin C

“ Chloroquine synergistically inhibited blast progenitor SR in suspension with vitamin C , resveratrol, NS-398 and Ind in four, six, one and five cell lines, respectively, in a total of 16 out of 28 conditions.”

“Results: Chloroquine synergistically inhibited blast colony formation in methylcellulose with vitamin C , resveratrol, NS-398 and Ind in one, two, none and one cell lines, respectively, in a total of four out of 28 conditions.”

“Co-treatment with ascorbic acid has prevented both chloroquine-induced ROS production and chloroquine toxicity on glial cell cultures.”

“In the present study vitamin C pretreatment apparently reduced the frequency of CA, MN, and SA induced by CHQ.”

“ Chloroquine also caused significant reductions in the contents of reduced glutathione and ascorbic acid in the brain and erythrocytes with a significant increase in lipid peroxidation.”

“The oral administration of chloroquine in doses of 80 mg/kg and more produced a significant decrease in cholesterol and ascorbic acid concentrations in the suprarenal glands of female rats, while in males chloroquine in any of the dose levels tested was without effect.”

“The level of oxidative stress induced by Vc is significantly higher in iRBCs than uninfected RBCs, not seen in chloroquine or artemisinin-treated iRBCs, and effective in inhibiting chloroquine or artemisinin-resistant parasites.”