supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Chloroquine
supplement:
Vitamin A
Research Papers that Mention the Interaction
“In this study, we demonstrate that CQ and HCQ could markedly impair atROL uptake in OATP1A2-expressing HEK293 cells and more importantly, in primary human RPE cells.”
Chloroquine and Hydroxychloroquine Are Novel Inhibitors of Human Organic Anion Transporting Polypeptide 1A2.“Cell surface membrane-active agents, such as chloroquine , hydrocortisone and chlorpromazine inhibited cytotoxicity, while vitamin A caused enhancement.”
“Although the parasites were highly resistant against 4-aminoquinolines, significant synergism was observed between chloroquine and retinol as well as amodiaquine and retinol, the latter at physiological concentrations.”
“Combination with retinol reduced the geometric mean concentrations effecting complete inhibition (GMCOC) by chloroquine from 14425 nM to 8943 nM in CHL-RET low, 7042 nM in CHL-RET medium, and 4920 nM in CHL-RET high.”
Pharmacodynamic interaction between 4-aminoquinolines and retinol in Plasmodium falciparum in vitro
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback