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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Chloroquine
supplement:
Thiamine
Research Papers that Mention the Interaction
“Furthermore, metformin as well as other drugs including phenformin, chloroquine , verapamil, famotidine, and amprolium inhibited hTHTR-2 mediated uptake of both thiamine and metformin.”
Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3).“By taking a novel functional genomics strategy, which employs a unique combination of genome-wide drug-gene synthetic lethality (DGSL), gene-gene … dosage suppression (DS) screens in the model organism Saccharomyces cerevisiae and is thus termed SL/DS for simplicity, we found that CQ … thiamine transporters Thi7, … in yeast.”
“In addition, CQ completely inhibited a human thiamine transporter (SLC19A3) expressed in yeast and significantly inhibited thiamine uptake in cultured human cell lines.”
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