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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Chloroquine
supplement:
Resveratrol
Research Papers that Mention the Interaction
“ CQ with UA or RES strongly and synergistically reduced the viability of B16F10 mouse melanoma and A375 human melanoma cells.”
“In addition, CQ plus RES synergistically decreased the levels of both autophagy initiator beclin-1 and autophagy supporter p62.”
“Surprisingly, flow cytometry of acridine orange-stained cells showed that UA or RES in combination with CQ significantly reduced autophagosome levels.”
“These results indicate that CQ with UA or RES strongly and synergistically reduces the viability of B16F10 and A375 melanoma cells.”
“Western blotting analysis revealed that CQ plus UA or RES paradoxically increased LC3II, indicative of autophagosome accumulation.”
Ursolic acid and resveratrol synergize with chloroquine to reduce melanoma cell viability“ Chloroquine synergistically inhibited blast progenitor SR in suspension with vitamin C, resveratrol , NS-398 and Ind in four, six, one and five cell lines, respectively, in a total of 16 out of 28 conditions.”
“Results: Chloroquine synergistically inhibited blast colony formation in methylcellulose with vitamin C, resveratrol , NS-398 and Ind in one, two, none and one cell lines, respectively, in a total of four out of 28 conditions.”
“Knockdown of autophagy-related protein 5 or inhibit the lysosomal degradation by chloroquine (CQ) decreased the effect of RSV.”
“Collectively, results unravel the effects of resveratrol on TIGAR in mediating its ROS dependent influence and suggest a better combination therapy of resveratrol and chloroquine for probable cancer treatment.”
“The clearance of damaged mitochondria and ROS reduction by resveratrol was completely suppressed by an autophagy inhibitor ( chloroquine ) and by knocking down Atg5 or Pink1, essential genes for autophagy and mitophagy, respectively.”
Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice“The autophagy inhibitor, chloroquine not only eliminated the preventive effect of resveratrol , but also turned it to deleterious suggesting the prominent role of autophagy induction in the cytoprotective effect.”
“Treatment with chloroquine reversed effect of resveratrol.”
“When resveratrol and chloroquine were administered together, the effects offset one another.”
“Pretreatment with the autophagy inhibitor chloroquine could reduce the protective effects of resveratrol.”
Sirt3-Mediated Autophagy Contributes to Resveratrol-Induced Protection against ER Stress in HT22 Cells“Combination treatment with CQ and RSV more robustly suppressed growth inhibition and apoptosis, compared with RSV treatment alone.”
“Combination treatment with RSV and an autophagy inhibitor, such as CQ , may be an attractive therapeutic option for treating certain endometrial cancer cells.”
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