Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Chloroquine and Quinine

drug:

Chloroquine

supplement:

Quinine

Research Papers that Mention the Interaction

“ Chloroquine has been reported to antagonise the anti-parasitic action of quinine against Plasmodium falciparum in vitro.”
Efficacy of quinine for falciparum malaria according to previous chloroquine exposure
The Lancet  •  1991  |  View Paper
“The IC50, IC90 and geometrical mean MIC for quinine were all about two times higher for the chloroquine-resistant than for the chloroquine-sensitive isolates (P = 0.006).”
Susceptibility of Plasmodium falciparum to different doses of quinine in vivo and to quinine and quinidine in vitro in relation to chloroquine in Liberia.
Bulletin of the World Health Organization  •  1991  |  View Paper
“Quinine should not be used in short courses, nor does the combination of quinine and chloroquine have any advantage.”
Treatment of uncomplicated malaria in children in Guinea-Bissau with chloroquine, quinine, and sulfadoxine-pyrimethamine.
Transactions of the Royal Society of Tropical Medicine and Hygiene  •  2002  |  View Paper
“In each study, the response to quinine was significantly higher than that to chloroquine (P = 0.004 and < 0.001, respectively).”
Response of uncomplicated falciparum malaria to oral chloroquine and quinine in Burundi highlands.
Acta tropica  •  1998  |  View Paper
“There was a significantly positive but weak correlation between the IC(50) values of CQ and QN , as well as between the IC(50) values of QN and MQ.”
Drug resistance and in vitro susceptibility of Plasmodium falciparum in Thailand during 1988-2003.
The Korean journal of parasitology  •  2009  |  View Paper
“The median inhibitory concentrations (IC50) of chloroquine were positively correlated with those of quinine (r=0.4528; P=0.0008) but not those of any of the other drugs investigated.”
The in-vitro susceptibilities of Ghanaian Plasmodium falciparum to antimalarial drugs
Annals of tropical medicine and parasitology  •  2007  |  View Paper
“The mean IC(50) of monodesethylamodiaquine, quinine and dihydroartemisinin was significantly higher for chloroquine-resistant than for chloroquine-sensitive strains (P<0.05).”
In-vitro susceptibility of Plasmodium falciparum to monodesethylamodiaquine, dihydroartemisinin and quinine in an area of high chloroquine resistance in Rwanda.
Transactions of the Royal Society of Tropical Medicine and Hygiene  •  2006  |  View Paper
“This alkaloid was found to enhance the action of chloroquine against chloroquine-resistant strains of Plasmodium falciparum when combined with classical antimalarial drugs (chloroquine, quinine).”
Isolation from rat urine and human liver microsomes and identification by electrospray and nanospray tandem mass spectrometry of new malagashanine metabolites.
Journal of mass spectrometry : JMS  •  2000  |  View Paper
“ Chloroquine inhibited quinine 3-hydroxylation with rat and dog liver microsomes but not with human liver microsomes.”
The In vitro hepatic metabolism of quinine in mice, rats and dogs: comparison with human liver microsomes.
The Journal of pharmacology and experimental therapeutics  •  1997  |  View Paper
“The IC50 for QN was significantly higher in CQ-resistant strains and there was a positive correlation for CQ vs QN and for QN vs MQ.”
In vitro drug sensitivity and clinical aspects of Plasmodium falciparum malaria in African children.
Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit  •  1995  |  View Paper
Show More