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“The risks of fast intravenous injection of quinine, the striking prolongation of the electrocardiographic (ECG) QT interval triggered by quinidine , and the lethality of CQ in overdose have separately caused substantial concern.”
European heart journal. Cardiovascular pharmacotherapy • 2020 | View Paper
“As reported previously for other HERG blockers (e.g., MK-499, cisapride, terfenadine, chloroquine ), the potency of quinidine was reduced >100-fold by the mutation of key aromatic residues (Y652, F656) located in the S6 domain.”