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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chloroquine
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“ Chloroquine inhibits growth of other intracellular pathogens by limiting iron availability.”
Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivation.“Both desferrioxamine (DFO) and chloroquine can significantly reduce hepatic iron in experimental animals with iron overload by chelating iron from the low-molecular-weight pool or decreasing iron uptake by the transferrin-transferrin receptor cycle, respectively.”
Changes in function of iron-loaded alveolar macrophages after in vivo administration of desferrioxamine and/or chloroquine.“ Chloroquine significantly reduced incorporation of iron into the liver, spleen, and alveolar macrophages of animals loaded in vivo with iron dextran.”
“Abstract: The effect of chloroquine , a lysosomotropic agent, on iron uptake into neuronal and glial cell cultures is reported.”
“The lysosomotropic agents W C l and chloroquine inhibit iron uptake into the cells without inhibiting internalization of transferrin, a result suggesting that the lysosome is an important intermediate in the iron-uptake pathway.”
“We rather assume an effect of CQ on the metabolism of iron.”
“ Chloroquine is shown to increase the uptake of iron into the blood cells of uninfected mice to suggest another action of chloroquine.”
“The protective effect of iron is increased approximately 3-8 times by chloroquine injections.”
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