Possible Interaction: Chloroquine and Calcium Supplement

“ Chloroquine therapy was associated with a significant reduction in levels of serum 1,25-dihydroxyvitamin D (1,25(OH)2D) and urinary calcium.”

“ Chloroquine also blocked the dialyzed inositol-1,4,5-trisphosphate (IP₃)-induced intracellular Ca ²⁺ increase.”

“Conclusion: These … that chloroquine inhibits the … of intracellular Ca ²⁺ in thymic CD4⁺ T cells by inhibiting IP₃ receptor-mediated Ca^…+ release from intracellular stores and TRPC3 channel-mediated and/or STIM/Orai channel-mediated Ca²⁺ influx.”

“Results: In murine CD4⁺ thymocytes, chloroquine decreased the TG-triggered intracellular Ca ²⁺ increase in a dose-dependent manner.”

“These results indicate that chloroquine and amodiaquine may bind with calcium making it unavailable for PLD activation.”

“For thrombin-stimulated aggregation the effect of chloroquine was partially decreased by corresponding isomolar calcium ; platelet aggregation induced by ADP was not changed in the presence of extracellular Ca2+ ions.”

“PA secretion at high Ca ], like that of PTH, was increased by treatment of cells with chloroquine and/or 3-methyladenine.”

“Inhibition of cecal Ca Jm----s by mucosal chloroquine (0.1 mM) or ammonium chloride (10 mM) varied from 37 to 50%.”

“Restoration of Ca++ to Ach-stimulated "Ca-depleted" tissues produced contractions due to Ca++ influx; these contractions were prevented by chloroquine , dose-dependently.”

“ Chloroquine increased the rabbit ileal calcium content and decreased 45Ca2+ influx from the serosal surface.”

“The observations indicate that calcium ions are able to reverse the cardiodepression induced by chloroquine and quinine.”

“ Chloroquine decreased intracellular calcium by >50% concomitant with a decrease in glucose transport.”