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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chloroquine
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Here we show that chloroquine (200 µM) also appears to block the storage of newly synthesized ACTH in secretory granules and instead diverts it to the outside of the cell via the constitutive pathway.”
Chloroquine diverts ACTH from a regulated to a constitutive secretory pathway in AtT-20 cells“ Abstract Chloroquine hydrochloride , at 6.3 × 10 −5 M concentration, significantly suppressed in vitro the lipolytic actions of epinephrine, TSH, and bovine growth hormone, but not that of ACTH , as measured in the rat epididymal fat pad.”
“ Chloroquine (200 mUM from t=minus 2 h) significantly elevated the basal ACTH secretory rate (by 0.7 ± 0.2 ng over 30 min incubation, 1.1 ± 0.3 ng over 60 min and 2.3 ± 0.6 ng over 120 min).”
Chloroquine Decreases Adrenocorticotrophin‐Secretory Response to Corticotrophin‐Releasing Factor but not to Vasopressin in Rat Pituitary Cells: Further Evidence for Differentially Responsive Subpopulations
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