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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chlorogenic Acid
supplement:
Silymarin
Research Papers that Mention the Interaction
“Our … simultaneous SILY … CGA administration caused a significant decrease in hepatic apoptosis biomarkers (hepatic caspase-3 and nuclear factor-κB levels), a significant improvement in hepatic oxidant/… and superoxide dismutase) and significant decrease in hepatic pro-inflammatory biomarkers (tumor necrosis factor-alpha and interlukin-1β) compared with DOX treatment.”
“We concluded that adding CGA to SILY acts as a hepatoprotective agent against DOX-induced liver injury through inhibiting apoptosis biomarkers, maintaining antioxidant enzyme levels, decreasing pro-inflammatory cytokines as well as regulating liver adenosine monophosphate-activated protein kinase signaling.”
Silymarin in combination with chlorogenic acid protects against hepatotoxicity induced by doxorubicin in rats: possible role of adenosine monophosphate-activated protein kinase pathway.“All beneficial effects of SIL were markedly potentiated when combined with CA and/or ME.”
“The significantly intensified hepatoprotective effects of SIL when combined with both CA and ME suggest a possible synergism.”
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