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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Chlorogenic Acid
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“The molecular docking and fluorescence spectroscopy demonstrate that CGA had a static quenching effect on rHSA with one binding site, and the range of K values was 7.14 × 103 to 1.56 × 104 M-1.”
Purification of chlorogenic acid from Heijingang potatoes and evaluation of its binding properties to recombinant human serum albumin.“CCA presented the strongest ability of hydrogen-bond formation, and both CA and NCA generated more electrostatic interactions with HSA.”
“Site marker competitive displacement experiments demonstrated that CGA specific bind to site I (subdomain IIA) of HSA.”
“Binding of chlorogenic acid induces conformational change in HSA as indicated by quenching of fluorescence emission intensity along with a red shift in the emission maxima from 338 to 350 nm.”
“Far-ultraviolet circular dichroic data showed a decrease in the alpha-helical content of HSA from 56 to 50% upon binding of CGA.”
“These data are also supported by the decrease in the apparent Tm of HSA by 4 degrees C upon binding of CGA causing destabilization of the HSA molecule.”
“These high Ka-values showed that the interaction between CGA and HSA is strong, endothermic and entropically driven.”
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