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“ CA alleviated ROS production and prevented the reduction of antioxidant capacity in cells exposed to PQ by increasing NF-E2-related factor 2 (Nrf2), superoxide dismutase 2 (SOD2) and glutathione levels.”
“Mechanistic studies revealed that CA upregulates a panel of phase II cytoprotective species, such as heme oxygenase-1, NAD(P)H: quinone oxidoreductase 1, glutathione , thioredoxin reductase 1, and thioredoxin 1.”
“Further biochemical assays showed that ICAC modulated several antioxidant enzymes involved in reduced and oxidized glutathione ( GSH and GSSG) homeostasis, including glutathione reductase (GR), glutathione peroxidase (GPX), and glucose-6-phosphate dehydrogenase (G6PD), resulting in restoration of the GSH/GSSG ratio and reactive oxygen species (ROS) level.”
“This study indicated that ICAC acted as an antioxidant and prevented EV71 infection by modulating the redox homeostasis of glutathione.”
“However, supplementation with CGA decreased serum concentrations of lactate, pyruvate, succinate, citrate, β-hydroxybutyrate and acetoacetate, while increasing serum concentrations of glycine and hepatic concentrations of glutathione.”
The Journal of nutritional biochemistry • 2013 | View Paper
“ CGA not only suppressed the generation of ROS, the decrease of activity in GPx and the decrease of GSH , but also attenuated caspase-3 activation in PC12 cells by MeHg.”