Possible Interaction: Chlorogenic Acid and Glutathione

“Furthermore, AE, as well as ChA , prevented the loss of total GSH and the accumulation of MDA.”

“ CA alleviated ROS production and prevented the reduction of antioxidant capacity in cells exposed to PQ by increasing NF-E2-related factor 2 (Nrf2), superoxide dismutase 2 (SOD2) and glutathione levels.”

“Mechanistic studies revealed that CA upregulates a panel of phase II cytoprotective species, such as heme oxygenase-1, NAD(P)H: quinone oxidoreductase 1, glutathione , thioredoxin reductase 1, and thioredoxin 1.”

“Further biochemical assays showed that ICAC modulated several antioxidant enzymes involved in reduced and oxidized glutathione ( GSH and GSSG) homeostasis, including glutathione reductase (GR), glutathione peroxidase (GPX), and glucose-6-phosphate dehydrogenase (G6PD), resulting in restoration of the GSH/GSSG ratio and reactive oxygen species (ROS) level.”

“This study indicated that ICAC acted as an antioxidant and prevented EV71 infection by modulating the redox homeostasis of glutathione.”

“ Chlorogenic acid decreased malondialdehyde levels as well as increased reduced glutathione and superoxide dismutase levels in the flap tissues.”

“ CGA decreased MDA level and increased GSH , SOD and CAT levels in liver tissues.”

“However, supplementation with CGA decreased serum concentrations of lactate, pyruvate, succinate, citrate, β-hydroxybutyrate and acetoacetate, while increasing serum concentrations of glycine and hepatic concentrations of glutathione.”

“Moreover, CGA reversed AP-decreased liver reduced glutathione ( GSH ) levels, glutamate-cysteine ligase (GCL) and glutathione reductase activity.”

“ CGA not only suppressed the generation of ROS, the decrease of activity in GPx and the decrease of GSH , but also attenuated caspase-3 activation in PC12 cells by MeHg.”