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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Chlormethiazole
supplement:
Glycine
Research Papers that Mention the Interaction
“These observations suggest that the active steroids and chlormethiazole increase the functional interaction of both glycine and strychnine with the glycine-gated chloride channel.”
Steroid modulation of the strychnine-sensitive glycine receptor“Applied micro-iontophoretically, chlormethiazole was found to potentiate the inhibitory responses to GABA, muscimol and glycine , but not to acetylcholine.”
“3 When applied with lower currents CMZ did not cause changes in firing rate, but enhanced the inhibitory effects of γ‐aminobutyric acid (GABA), muscimol and glycine in a dose‐dependent manner.”
“5 Intraperitoneal administration of CMZ (50–600 μmol kg−1) also enhanced responses to microiontophoretically applied GABA, muscimol and glycine.”
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