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Last Updated: 4 months ago

Possible Interaction: Chlormethiazole and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

IMPLICATIONS Enhancement of gamma-aminobutyric acid(A)-mediated effects by clomethiazole (CMZ) and associated neuroprotection has been established in animal models of cerebral ischemia.
Anesthesia and analgesia  •  2003  |  View Paper
A low concentration of clomethiazole (30 micro M) also potentiated the action of GABA in both cell types, equivalent to a 3-fold increase in potency and up to 1.8-fold increase in maximal current.
Both direct activation and gamma-aminobutyric acid potentiation are likely to contribute to the in vivo profile of clomethiazole.
European journal of pharmacology  •  2002  |  View Paper
At an antiepileptic concentration (300 microM), chlormethiazole potentiated the action of exogenously applied GABA (1 mM) but did not affect responses to the glutamate receptor agonists N-methyl-D-aspartate (10 microM) or L-quisqualic acid (3 microM).
Brain Research  •  2000  |  View Paper
Applied micro-iontophoretically, chlormethiazole was found to potentiate the inhibitory responses to GABA , muscimol and glycine, but not to acetylcholine.
These findings suggest that chlormethiazole may enhance GABA transmission beyond the GABA receptors, hypothetically at the level of the GABA receptor coupled ionophore (e.g. the chloride ion channel).
Acta psychiatrica Scandinavica. Supplementum  •  1986  |  View Paper
Intraperitoneal administration of CMZ (50-600 mumol kg-1) also enhanced responses to microiontophoretically applied GABA , muscimol and glycine.
When applied with lower currents CMZ did not cause changes in firing rate, but enhanced the inhibitory effects of gamma-aminobutyric acid (GABA), muscimol and glycine in a dose-dependent manner.
British journal of pharmacology  •  1983  |  View Paper