Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Chlorine and Glycine



Research Papers that Mention the Interaction

Chlorine , and other small electron-withdrawing substituents in the 4- … ring, greatly enhanced binding and selectivity for the glycine site over the glutamate site of the NMDA receptor; one of the most potent compounds is …-3-yl)propionic acid (IC50 = 170 nM; greater than 2100-fold selective for glycine).
Journal of medicinal chemistry  •  1992  |  View Paper
The data reveals that while fluorine and chlorine have strong tendencies favoring interactions with the backbone Lewis bases at glycine , the trend is not restricted to the achiral amino acid backbone for larger halogens.
J. Chem. Inf. Model.  •  2013  |  View Paper