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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Chlorine , and other small electron-withdrawing substituents in the 4- … ring, greatly enhanced binding and selectivity for the glycine site over the glutamate site of the NMDA receptor; one of the most potent compounds is …-3-yl)propionic acid (IC50 = 170 nM; greater than 2100-fold selective for glycine).”
3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site.“The data reveals that while fluorine and chlorine have strong tendencies favoring interactions with the backbone Lewis bases at glycine , the trend is not restricted to the achiral amino acid backbone for larger halogens.”
Halogen Interactions in Protein-Ligand Complexes: Implications of Halogen Bonding for Rational Drug Design
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